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San Diego starter Anthony Bass struggled with his control and couldn't make it through five innings. He was pulled after walking in a run with two out in the fifth -- his third walk of the inning.
Miles Mikolas walked in another run in relief before Alex Hinshaw came on to end the inning.
Bass was charged with five runs over 4 2-3 innings. He walked four and struck out two.
Dempster lasted just 4 1-3 innings and remained winless in nine starts on the year. He gave up six runs -- all on homers. He was pulled one batter after Quentin's second shot.
The Cubs bullpen combined for 4 2-3 scoreless innings.
"We don't win that game if they don't do the job they did," Dempster said.
In the second inning, Steve Clevenger knocked in a run with a single in his first at-bat since coming off the disabled list, then doubled in another run two innings later. He came up with the bases loaded and two out in the fifth but grounded out to second base.
Clevenger missed over a month due to a strained right oblique. He was 11 for 22 before going on the DL, and maintained a .500 average with a 2 for 4 day.
NOTES: Game time temperature was 59 degrees, a 31-degree difference from Monday's 90-degree opener. ... Padres OF Cameron Maybin (sprained right wrist) played for the first time since leaving in the sixth inning of Saturday's 9-0 loss to the New York Mets. Maybin pinch-ran for Quentin in the ninth. ... RHP Huston Street (right shoulder strain) threw a high-intensity bullpen session on Wednesday. He is expected to make his first rehab appearance on Friday with Class A Lake Elsinore against the Racho Cucamonga Quakes. ... Clayton Richard (2-6, 4.76 ERA) starts Friday for San Diego as the Padres a six-game homestand against Arizona. Paul Maholm (4-3, 4.62) will open a 10-game road trip for the Cubs on Friday in San Francisco.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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