Officials with the Butler County Emergency Operations Center say in a statement the bus, carrying 52 people, was headed northbound on I-75 when it overturned about 26 miles north of Cincinnati at approximately 4 a.m.
Authorities say 34 people have been transported to area hospitals. They say six were taken from the scene by medical helicopters, and 28 others taken to hospitals by ambulance.
Officials say the bus was bound for Detroit.
There was no immediate word on the cause of the crash.
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