AstraZeneca and Lilly move Alzheimer's drug into big trial
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[December 01, 2014]
LONDON (Reuters) - AstraZeneca and
Eli Lilly said on Monday they had started a large trial of their
experimental Alzheimer's drug, seen as a promising, but still risky,
approach for slowing the memory-robbing disease.
The pivotal Phase II/III clinical trial will involve more than 1,500
patients with early Alzheimer's, the first one of which has now been
enrolled. The study is expected to complete in May 2019, according
to the clinicaltrials.gov website.
AstraZeneca, which initially developed the drug, signed a
partnership deal with Lilly in September for the product, known as
AZD3293 or LY3314814.
The medicine works by blocking an enzyme called beta secretase that
is involved in production of beta-amyloid, a protein that creates
brain plaques. Such medicines are known as BACE inhibitors.
Merck & Co is currently viewed as being in the lead in the BACE
inhibitor field, having announced plans for a Phase III trial a year
Oral drugs to block beta secretase have taken centerstage after an
injectable class of medicines, meant to remove plaque once it has
already formed, disappointed in trials conducted by Pfizer and Eli
Lilly in 2012.
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(Reporting by Ben Hirschler, editing by Louise Heavens)
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