U.S. gene study raises hope for Merck
cholesterol drug Zetia
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[November 13, 2014] By
CHICAGO (Reuters) - Rare mutations in a
single gene may help lower cholesterol and reduce the risk of a heart
attack by half, U.S. researchers said on Wednesday in a study that could
have implications for Merck and Co's closely watched heart drug Zetia.
The study involved individuals with mutations in a gene called
NPC1L1, the gene targeted by Zetia, a cholesterol fighter known
generically as ezetimibe.
While common cholesterol fighters known as statins keep the body
from making cholesterol, Zetia blocks the body's ability to absorb
cholesterol in the gut. And while there is clear evidence that
statins reduce the risk of heart attacks, there is scant evidence to
show that Zetia does much more than lower cholesterol.
That is where the new genetic study comes in.
Researchers at the Broad Institute and Washington University in St.
Louis combed through data on some 113,000 people from multiple
studies looking for individuals with rare mutations that shut off
the activity of NPC1L1.
They found 82 people who inherited a single mutated copy of this
gene, leaving them with one working copy. Among these individuals,
LDL cholesterol, the so-called "bad" cholesterol, was 10 percent
lower than in individuals in the study with two working copies of
People with the mutated gene also had half the risk of heart disease
as people with two working copies.
Although the findings cannot be used to draw direct conclusions
about Zetia, they do suggest that the drug may be hitting an
important target for reducing the risk of heart attacks, study
author Dr. Nathan Stitziel of Washington University School of
Medicine in St. Louis said in a statement.
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"Whether ezetimibe specifically is the best way to target NPC1L1
remains an open question," he said.
That answer may come on Monday when Merck releases the long-awaited
results from the large clinical trial called IMPROVE-IT. That trial
looks specifically at whether people who took statins plus ezetimibe
were less likely to have heart attacks than people who took statins
The gene analysis study was funded in part by grants from Merck as
well as the National Institutes of Health and the Canadian
Institutes of Health.
(Reporting by Julie Steenhuysen; Editing by Cynthia Osterman)
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