Researchers surveyed 517 adults who had donated a piece of their
liver three to 10 years earlier at nine transplant centers in the
U.S. and Canada.
“We were surprised donors continued to report some issues,” study
leader Mary Amanda Dew told Reuters Health by phone. “We thought by
the time they were so far out from the date they donated part of
their livers, they might not have difficulties.”
Previous reports had tracked donors for only a year or two after
donation. Their longer-term health and quality of life hasn’t been
well studied, she said.
Organ donors are highly screened and are generally healthy
psychologically and physically, she noted. In this study, however,
even many years after donation, many were reporting problems that
were clearly linked to their original surgery, she said.
Seventy-eight donors, or 15 percent, reported donation-related
medical problems – most often hernias, digestive issues, chronic
diarrhea, and problems with scar tissue.
Also, 111 donors said they could not do some physical activities as
well as they could before donation. In particular, the limitations
involved exercises or activities requiring abdominal strength,
vigorous physical activity, and lifting significant weight.
Finally, up to about a third of the donors reported health worries
due to donation, with concern about future health being most
Still, more than 90 percent of donors said they would make the same
decision to donate again, and most had positive overall feelings
The good news, according to Dew, is that donors’ general quality of
life was as good as or better than for others in their peer group.
Even if the transplant recipient didn’t survive, donors felt
positively about the donation, she said.
There’s a psychological benefit to knowing you did everything you
could to save someone’s life, Dew said.
“Another important issue concerns financial burdens donors may have
due to the donation,” Dew said. “We are aware that this financial
burden exists. We need organs but it’s unfair for donors to have to
take on this financial burden.”
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Based on their responses, the researchers were able to divide
participants into five distinct “clusters.” The largest consisted of
158 donors with a high degree of physical concerns and some
socioeconomic concerns, along with some psychological benefit.
The next two largest clusters each contained 109 donors. In one of
these groups, donors reported high psychological benefit but some
degree of physical and socioeconomic concerns. In the other, donors
didn’t get much psychological benefit from donating but they also
didn’t have much in the way of physical and socioeconomic concerns.
The fourth largest group, with 74 donors, had the best outcomes,
with the highest psychological benefit and mostly low physical and
And finally, the smallest group consisted of 57 donors with the
lowest psychological benefit plus some physical and socioeconomic
Dr. Rohit Loomba, a member of the American Liver Foundation’s
National Medical Advisory Committee, told Reuters Health by email
that physical and financial effects “several years down the road”
after liver donation is a new finding.
Loomba, who wasn’t involved in the study, told Reuters Health by
email, “Finding five different groups helps us peek into how we can
move donors from one pool to another to minimize physical and
financial burden in future.”
SOURCE: http://bit.ly/1sOzKvz Transplantation, online May 6, 2016.
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