Golden State, which snapped a two-game losing streak, had six players in double figures. Monta Ellis scored 19 points, while Kelenna Azubuike added 15 points and 10 rebounds. Stephen Jackson finished with 14 points, Marco Belinelli had 13 and Brandan Wright scored 10.
The Warriors are a half-game behind idle Denver for the final playoff spot in the West. Biedrins shot 8-of-11 from the field and grabbed five offensive rebounds.
Rudy Gay led Memphis with 23 points, while Hakim Warrick finished with 13 and Kyle Lowry had 12.
The win gave the Warriors a season sweep of Memphis. Golden State, which has won seven straight over Memphis, had not recorded a four-game sweep of the Grizzlies since 1995-96, although the Warriors won all three games in the lockout-shortened 1998-99 season.
Biedrins dominated the middle, spinning around Memphis defenders and connecting on high-percentage inside shots. Ellis also was getting to the basket, including several on fast breaks, and Memphis seemed unwilling to get in the Warriors' way.
Biedrins already had a double-double with 9 minutes left in the first half, and the Warriors built a 19-point lead before carrying a 60-46 advantage into the dressing room.
As is the case with both teams, there was little defense, but the Warriors converted Memphis' lack of resistance into 56 percent shooting in the first half, and finished the night shooting 54 percent.
Biedrins and Ellis had 14 points apiece at the half, while Azubuike had 10.
At times, the play was sloppy, and the Warriors' 12 first-half turnovers prevented them from extending the lead.
Golden State continued to pull away after halftime, starting with a 7-1 run as Memphis missed seven of its first eight shots. The Warriors held a 28-point lead in the third and led 90-66 entering the fourth.