Six massive fighting bulls slipped on morning dew-dampened cobblestones and tossed people aside as they ran with them on the half-mile course through the narrow city streets to the bull ring.
The Navarra government said a 26-year-old Colombian man was taken to Virgen del Camino hospital with a gored right buttock, a 33-year-old man from Ghana suffered a broken jaw and a Barcelona man, 55, will require plastic surgery on his right ear.
In minor injuries, a 29-year-old Madrid resident broke his nose and a 26-year-old from Lesaka fractured his left wrist, the government said.
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Minutes before the run began, police cleared the streets of about a half-dozen animal rights protesters.
The run - the sixth in the weeklong adrenalin and alcohol-fueled annual festival
- was quick, lasting less than three minutes despite an unusually large weekend crowd in which serious bull running aficionados were joined by revelers.
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At least three of the fierce animals from the renowned Dolores Aguirre Ybarra ranch fell, despite being accompanied by guiding steers and staff-carrying bullherds.
One runner was caught between the horns of a bull, hit first by its left horn then the right one, before being nudged to the side. That runner avoided a goring.
Several people were caught in a crush of festivalgoers and forced to dive for cover as the bulls approached, suffering cuts and bruises in the process.