The Pacific Division-leading Lakers went 12-of-17 from 3-point range in the second half after making just two of six from beyond the arc in the first two quarters.
Fisher finished 3-for-4 from behind the line, Bryant went 2-for-3, Jordan Farmar and Coby Karl each went 2-for-2, and Vladimir Radmanovic and Sasha Vujacic 2-for-4.
The Lakers' 61 percent from 3-point range was better than their overall shooting percentage
- 54 percent.
Lamar Odom added 15 points and Ronny Turiaf had 13 for the Lakers. Radmanovic, Pau Gasol and Farmar each scored 10 to give them seven players in double figures.
The Pacific cellar-dwelling Clippers were good on just 3-of-14 from 3-point range as they lost for the seventh time in eight games.
Corey Maggette had 22 points, seven rebounds and three assists in the loss. Chris Kaman had 14 points and 11 rebounds, but scored only four points after the first quarter. Cuttino Mobley added 13 points for the Clippers.
The Lakers broke the game open with a 13-2 burst that began with Luke Walton's 18-footer in the final second of the first half, and ended on Fisher's 3-pointer for a 62-43 lead in the first 3:15 of the third quarter.
Fisher scored nine points in the first half. Bryant and Gasol scored eight apiece.
The Lakers were up 26-24 at the end of the first quarter, with Kaman's 10 points helping the Clippers keep it close. Bryant took just three shots but made all three, was good on two shots from the free throw line and had eight points in the first 12 minutes.
