"It should be an exciting and unusual event," Sacks said in an interview this week. "I will talk about the therapeutic and beneficent power of music as a physician, and then their wonderful choir will perform. ... And the audience will make what they can of it."
Sacks' most recent book is "Musicophilia: Tales of Music and the Brain," which examines the relationship between music and the brain, including its healing effect on people suffering from such diseases as Tourette's syndrome, Parkinson's, autism and Alzheimer's.
"Even with advanced dementia, when powers of memory and language are lost, people will respond to music," he said.
A Baptist church is an unusual venue for Sacks, a professor of clinical neurology and clinical psychiatry at Columbia University Medical Center who was brought up Jewish but is not a religious believer.
But the central role of music in church makes Abyssinian a good place to discuss the myriad ways that music affects the human brain, said Sacks, who was played by Robin Williams in the movie version of "Awakenings."
Abyssinian's pastor, the Rev. Calvin O. Butts III, said the choir is looking forward to performing with Sacks. He noted that music plays a central role in the healing power of prayer.
"What we have been studying ... is that when you pray, there's actually a physiological change in the body," he said. "Music is very much a part of this. There are certain notes that generate in the human body a kind of peacefulness."
Abyssinian was founded by Ethiopian sea traders in 1808 and is celebrating its bicentennial. It is a popular destination for European tourists who line up around the block in Harlem for Sunday services.