And she has told Malawi's harrowing story in her documentary, "I Am Because We Are." With an audience thus far limited to isolated theater screenings, it will be screened for everyone with its TV premiere on Sundance Channel at 9 p.m. EST Monday (World AIDS Day).
The feature-length film was written, produced and narrated by Madonna (directed by Nathan Rissman). It consults experts including President Bill Clinton and Archbishop Desmond Tutu.
But the film's real power is its images, which are often dismaying but, here and there, reflect hope and a remarkable will to survive.
"I had many goals," said Madonna during a phone conversation from her Manhattan home a few days ago. "I did get to a point where I thought,
'I'm being overambitious, I'm trying to say too much, I'll never accomplish it.' But I feel proud of the fact that I did get to make all my points."
Among her points: an insistence that any crisis comes with solutions, however hard-won and piecemeal.
The film offers its audience a menu of constructive responses.
"If all you can do is live life in YOUR world in a way that shows you are responsible for the people around you, that's a course of action," said Madonna. "People can be of service in large ways and small."
The first wide exposure of "I Am Because We Are" may be coming at a propitious time, which befits the pop superstar who made it, with her knack for anticipating and identifying cultural trends.
On the eve of a new presidential administration, Americans seem set on a more idealistic path, however alarmed they may be by economic threats along the way.
"People really are going, 'Wow! I can no longer ignore what's going on around me.' There are changes in the air," she said.
Madonna's busy schedule continues apace. But the artistic life that drives it "is a world you create and you inhabit, to express yourself, and to inspire and reach out to other people," she explained. "It's also a consolation, a place you go to to protect yourself." That's true now, in particular, during her highly public split with Guy Ritchie, her husband of eight years, which she described as "not easy, I'm not going to lie."