Javier Vazquez (11-12) allowed two runs in six innings and Bobby Jenks recorded the final five outs for his 28th save in 31 opportunities.
The victory came at an opportune time for the White Sox, who, despite losing five of six, entered the game tied with Minnesota for first place in the American League Central. Chicago lost the first two games of the series with the Indians.
After one-out singles by Ben Francisco and Shin-Soo Choo off Matt Thornton in the eighth put runners on first and third, Jenks came on and got Ryan Garko to hit into a double play. Jamey Carroll led off the ninth with a single, but Jenks got Kelly Shoppach to hit into a double play and struck out Asdrubal Cabrera to end the game.
Due to injuries and scheduled days off, manager Ozzie Guillen was forced to go with a lineup that resemebled a spring training game. Left fielder Carlos Quentin (sore right forearm), center fielder Ken Griffey Jr. and third baseman Joe Crede (both with back tightness) were unavailable. Designated hitter Jim Thome was on the bench until pinch-hitting in the ninth and catcher A.J. Pierzynski was given the day off.
Vazquez and the makeshift lineup came through. The right-hander (11-12) didn't give up a hit until Shin-Soo Choo singled with one out in the fifth. Shortstop Orlando Cabrera nearly made a diving stop of the hard ground ball up the middle, but it was just beyond his reach and went into center field.
Vazquez retired the first eight hitters and didn't allow a baserunner until Asdrubal Cabrera drew a one-out walk in the third. He held the Indians scoreless until Jhonny Peralta's two-run double in the fifth.
Jeremy Sowers (2-8) retired the first nine bitters before walking Orlando Cabrera on a 3-1 pitch to begin the fourth. Brian Anderson hit a ground ball single past third baseman Andy Marte for Chicago's first hit.
After managing one hit in the first four innings, the White Sox scored four runs on five hits in the next two innings before Sowers was pulled with one out in the fifth.