Dozens of insurgents attacked the joint foot patrol in Helmand province's Kajaki district Wednesday, the statement said.
Following a firefight, the militants were forced into "secondary fighting position" before the combined patrol called in an airstrike that hit the militants, the statement said.
"Twenty militants were killed in the engagement," the statement said.
A series of clashes in the same region on Tuesday killed 31 militants.
Southern Afghanistan is the center of the Taliban-led insurgency, but also the world's largest producer of opium. According to the U.N., hundreds of millions of dollars from the illicit trade are used to fund the insurgency
Violence in Afghanistan is expected to surge this year. The U.S. is sending 21,000 additional forces
-- most of whom are going to the south -- to bolster the record 38,000 American troops already in the country in an attempt to tamp down an increasingly bloody Taliban insurgency.
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