McCain says he is examining Sotomayor's record as an appeals court judge to decide whether she understands the limits to judicial power. He voted against her when she was nominated to the appeals court.
A Senate vote is expected this week.
The Arizona Republican says the prospect of Sotomayor becoming the first Hispanic on the high court is part of the discussion, and calls her a great American success story.
Two of McCain's close Senate colleagues differ on Sotomayor. Arizona's Jon Kyl is voting against her while South Carolina's Lindsey Graham plans to vote to confirm.
McCain spoke to CNN's "State of the Union" for its Sunday broadcast.
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