The new U.S. administration has brushed off Pakistani criticism that the missile strikes fuel religious extremism and boost anti-American sentiment in the Islamic world's only nuclear-armed nation.
Pilotless U.S. aircraft are believed to have launched more than 30 attacks since July, and American officials say al-Qaida's leadership has been decimated. Pakistani officials say the vast majority of the victims are civilians.
Taliban fighters surrounded the compound targeted Saturday in the village of Shrawangai Nazarkhel and carried away the dead and wounded in several vehicles.
Intelligence officials, who spoke on condition of anonymity because they were not authorized to talk to the media, said the victims included about 15 ethnic Uzbek militants and several Afghans. Their seniority was unclear.
Two of the officials said dozens of followers of Pakistan's top Taliban leader, Baitullah Mehsud, were staying in the housing compound when it was hit.
Pakistan's former government and the CIA have named Mehsud as the prime suspect behind the December 2007 killing of former Prime Minister Benazir Bhutto near Islamabad. Pakistani officials accuse him of harboring foreign fighters, including Central Asians linked to al-Qaida, and of training suicide bombers.
The accounts of Saturday's incident could not be verified independently. The tribally governed region is unsafe for reporters. The U.S. Embassy had no comment, while Pakistani government and army spokesman were unavailable.
Pakistani leaders told visiting American envoy Richard Holbrooke earlier this week that the missile strikes kill too many civilians and undermine the government's own counterinsurgency strategy.
Still, many analysts suspect that Pakistan has tacitly consented to the attacks in order not to endanger billions of dollars in American and Western support for its powerful military and its ailing economy.
Pakistan's pro-Western government, led by Bhutto widower Asif Ali Zardari, has signed peace deals with tribal leaders in the northwest while launching a series of military operations of its own against hard-liners.
However, government forces are bogged down in several regions and Taliban militants have sustained a campaign that has included a string of kidnappings and other attacks on foreigners.