The agency said Thursday that the drugs were found in nine duffel bags off a remote stretch of highway in Jacumba, about 75 miles east of San Diego. The route is popular with traffickers bringing drugs into the U.S.
The precocious pooch was described as a 2-year-old male German shepherd.
Agents arrested two suspected illegal immigrants who allegedly brought the drugs across the border.
The marijuana is estimated to have a street value of about $380,000.