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Pittsburgh and Buffalo, N.Y., which made the most progress cleaning up their air, saw life spans increase by about 10 months. Los Angeles, Indianapolis and St. Louis were among the cities that saw gains in life expectancy of around five months.
The study was partly funded by the Centers for Disease Control and Prevention and EPA.
"This finding provides direct confirmation of the population health benefits of mitigating air pollution," Daniel Krewski, who does pollution research at the University of Ottawa in Canada, wrote in an accompanying editorial.
In a statement, the EPA said such studies provide critical information that can help the agency set standards on particulates. EPA data show that average particulate levels nationally have fallen 11 percent since 2000.
Last year, government researchers reported that U.S. life expectancy has surpassed 78 years for the first time. They attributed the increase to falling mortality rates for nine of the 15 leading causes of death, including heart disease, cancer, accidents and diabetes.
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