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Brandon Backe pinch-hit for Moehler in the bottom of the third, ending Moehler's shortest start since April, when he left after 2 1-3 innings in Pittsburgh with a sprained knee.
Lilly, meanwhile, allowed only Hunter Pence's double and a walk to Backe through the first five innings.
Backe, making his third relief appearance since coming off the disabled list on May 28, escaped a two-out, bases-loaded jam in the fifth when Theriot popped up.
The Cubs loaded the bases with two outs again in the sixth and this time, Blanco doubled to the right-field corner for a 7-0 lead.
Lilly retired 10 straight hitters before Miguel Tejada's two-out single in the Astros sixth. Lilly struck out Pence to end the inning.
"I don't even know how I missed some of his pitches," Pence said. "But he just has everything going different directions, and he is just really crafty and smart."
Aaron Heilman relieved Lilly with two outs in the seventh inning and struck out Maysonet. Heilman pitched a scoreless eighth before Marshall finished.
Notes: Astros 2B Kazuo Matsui (strained hamstring) will play for Double-A Corpus Christi between Wednesday and Saturday and will likely rejoin the lineup next week. Matsui ran the bases at Minute Maid Park before Tuesday's game. ... Cubs RHP Rich Harden will start Saturday's game against Minnesota, Piniella said. Harden, on the disabled list since May 18 with a back strain, threw 70 pitches in a rehab start for Iowa on Monday.
[Associated Press;
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