Patrol spokesman Cameron Roden says several passengers were ejected from the bus, which was traveling from Las Vegas to Bryce Canyon National Park on Monday at about 7 p.m. when it crashed on Interstate 15.
Roden says at least two passengers were critically injured and flown to separate hospitals.
Victims hadn't been identified late Monday night.
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Information from: The Salt Lake Tribune, http://www.sltrib.com/