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Randy Winn set up Holliday's hit with a one-out single and moved to third on Felipe Lopez's base hit to center with two down.
"We earned that one in the ninth inning with some great at-bats against Gregg, who's very tough," manager Tony La Russa said.
Ryan Franklin worked the ninth for his 14th save in 15 chances, completing the four-hitter.
The Blue Jays wasted a terrific start by Ricky Romero, who matched Carpenter with eight scoreless frames. The left-hander allowed eight hits -- four by Albert Pujols -- walked one and struck out five.
Winn finished with three hits for the Cardinals, who have won four of five.
The Cardinals loaded the bases with none out in the first, but Felipe Lopez was thrown out at the plate on Nick Stavinoha's fielder's choice and Romero got out of the jam by striking out David Freese and Colby Rasmus.
The Blue Jays put runners on first and second in the third, but Carpenter struck out Adam Lind to end the threat.
Pujols led off the eighth with a broken-bat double into the left-field corner but was caught in a rundown when Romero sprang off the mound to field Stavinoha's bunt attempt. Stavinoha took second on the play but Freese struck out and Rasmus flied out.
NOTES: The shutout was the sixth for St. Louis, while Toronto was blanked for the fifth time. ... St. Louis OF Ryan Ludwick, who left Tuesday's game with a sore left calf, was held out of the starting lineup, while OF Fred Lewis (day off) did not start for the Blue Jays. ... Toronto 3B Edwin Encarnacion cleared waivers and was outrighted to Triple-A Las Vegas. ... Cardinals RHP Adam Wainwright (10-4) faces Blue Jays RHP Brandon Morrow (4-5) in Thursday's series finale.
Copyright 2010 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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