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Holliday hit his 27th homer, a solo shot, off reliever Wade LeBlanc in the sixth.
St. Louis scored three times in the opening inning. The first three batters reached and scored against Latos.
Miguel Tejada hit his 299th career homer in the first to give San Diego a 1-0 lead.
Cardinals closer Ryan Franklin returned to the team and pitched one inning. He gave up a solo homer to Chase Headley in the ninth. Franklin had been at home in Oklahoma for a few days on personal business.
NOTES: Holliday leads the NL with 48 two-out RBIs. ... Adrian Gonzalez is 2 for 20 against the Cardinals this season. ... San Diego RHP Chris Young will make his first start since April 6 on Saturday. Young missed 144 games with a right shoulder strain.
Copyright 2010 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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