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Schumaker's hit ended the day for Zito, who allowed four runs, six hits and five walks in 5 1-3 innings to lose his first home start since getting booed off the mound on the final weekend of the regular season last year.
Holliday added an RBI single in the seventh, giving him four hits and three RBIs in just two games this season. Freese led off the eighth with his first homer off Guillermo Mota to make it 6-1.
The loss capped a celebratory weekend in San Francisco, where the Giants raised their World Series championship banner before Friday's home opener, handed out World Series rings Saturday and honored 2010 NL Rookie of the Year Buster Posey in a pregame ceremony Sunday.
After getting wins following the first two celebrations, the Giants fell short Sunday and now can get ready to play games without all the pomp and circumstance.
"I don't want to say it's a relief. We were looking forward to it," manager Bruce Bochy said. "There might have been a little hangover today. It's been a very emotional first couple of games here but their guy pitched well. Give him credit. That's where it starts. He was on top of his game."
NOTES: Posey was one of a handful of regulars who got the day off for the Giants, with CF Andres Torres sitting with a mild left Achilles' strain and SS Miguel Tejada getting a planned day off. ... Cardinals C Gerald Laird was hit in the helmet by Pablo Sandoval's broken bat on an RBI single in the first inning but stayed in the game.
[Associated Press;
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