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Pujols went 1 for 4 with a single one night after taking over the NL home run lead with 29. He is looking to hit 30 homers for the 11th consecutive season.
Paul opened the scoring when he led off the bottom of the first inning with his second home run of the season and third of his career.
The Cardinals tied it in the third as Rafael Furcal's two-out double drove in Theriot, who led off with a single and advanced to second on Westbrook's sacrifice bunt.
Doumit hit his sixth homer in the fourth on an 0-1 curveball to put the Pirates ahead. Walker and Garrett Jones led off the inning with singles and Doumit followed with a drive to right field.
"They capitalized on the mistakes that I made," Westbrook said. "I felt strong about my sinker and it's a little frustrating to get hurt on my fifth-best pitch on the home run."
David Freese's RBI single chased McDonald in the top of the sixth but Pittsburgh got the run back in the bottom of the inning on a throwing error by shortstop Furcal.
Walker doubled home a run in the seventh to push the Pirates' lead to 6-2.
The Pirates won the opener of their six-game homestand after going 0-7 the last time they were at PNC Park. It was their longest winless homestand in the franchise's 125-year history.
"We've already won one more game at home this time," Hurdle said with a smile. "Good for us."
NOTES: Pirates LF Jose Tabata, on the disabled list since June 27 with a strained left quadriceps, returned to Pittsburgh to be examined by team doctors after hitting .333 (11 for 33) with six doubles and two RBIs in nine games with Triple-A Indianapolis on a rehabilitation assignment. If cleared by doctors, Tabata could be activated Tuesday. ... St. Louis RHP Edwin Jackson is expected to make his next scheduled Saturday against the Cubs at Chicago. A cramp in his right hamstring forced Jackson out in the sixth inning of Sunday night's victory over Colorado. ... St. Louis signed OF Charlie Tilson, their second-round draft pick from New Trier (Ill.) High School, beating the midnight deadline for agreeing to terms with drafted players. ... Chris Carpenter (8-8) starts for St. Louis against Jeff Karstens (9-6) on Tuesday night in the middle game of the three-game series. Carpenter is 12-2 with a 2.24 ERA in 17 career starts against Pittsburgh and has also gone 7-1 with a 2.60 ERA in 10 starts since June 20. Karstens has won six of his last eight decisions.
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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