"I saw it, but a little too late though," Humber said. "I'm not as quick as I thought."
Humber was struck with one out. He fell to the ground as the ball bounded back to catcher Tyler Flowers.
"I was running to the dugout looking for towels, that's what my first impression was," manager Ozzie Guillen said. "There's a lot of things that go through your mind, just how lucky we are and how lucky he is."
Humber stood up immediately after the play ended and appeared to be alert as the club's medical staff checked on him, but was removed after a short delay. He lobbied to remain in the game.
"When you get hit like that in that spot, it was unfair to leave him in there to try to pitch," Guillen said. "I think we did the right thing to get him out of there."
Humber was struck above the right eye and was removed as a precautionary measure. He will evaluated again on Friday, when it likely will be determined if he can make his next start.
"As of right now, I feel good," Humber said. "Just got a little pop knot on my forehead. Other than that, I feel very fortunate.
"My wife was here, so obviously it's upsetting for her. She told me the fans were very supportive and had a lot of kind things to say to her, so I appreciate that."
Justin Masterson pitched six effective innings and Fukudome had a tiebreaking RBI triple for Cleveland, which pulled within 1 1/2 games of idle Detroit for the division lead. Matt LaPorta hit a two-run homer.
The Tribe opens a three-game series against the Tigers on Friday.
"It was good," Masterson said. "It was a much needed series. We wanted to take this final game. That's kind of been our motto to try and win each series as we go out."
Paul Konerko homered for the White Sox. Konerko, Adam Dunn and Omar Vizquel each had two hits, and Flowers singled in a run.
Masterson (10-7) allowed two runs and seven hits, struck out two and walked three. The 6-foot-6 right-hander improved to 2-2 with a 1.61 ERA in four starts against the White Sox this season.
The Indians won the last two games of their three-game series against the White Sox after losing seven of their first eight games against Chicago this season.
"They play good baseball against us," Indians manager Manny Acta said. "They hit us around pretty good at the beginning of the year, and they have played their best baseball against us."