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Lincecum had allowed only five runs over his previous five starts. He pitched out of jams in the first and sixth but gave up solo home runs to Soriano and Soto before DeWitt's three-run blast in the seventh.
The two-time NL Cy Young Award winner finished with four walks and four strikeouts. He needs seven more to reach 200 for the fourth consecutive season.
Soriano's home run was his 23rd of the season, one shy of tying Pena and Aramis Ramirez for the team lead.
The other three home runs all came in the seventh, including Pena's solo shot off reliever Steve Edlefsen. It's the first time the Cubs have hit three homers in one inning since June 9, 2010.
"We swung the bats great and Wellsie was something else," Chicago manager Mike Quade said. "To do that kind of damage against Lincecum was a huge plus. The offense was fantastic."
NOTES: Soto's homer leading off the seventh snapped an 0-for-25 streak by the Cubs' catcher. ... RHP Matt Garza (6-10) starts for the Cubs on Tuesday and will make his first career appearance against the Giants. Garza has only two wins and a 5.07 ERA on the road this season.
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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