Authorities say the accident Sunday evening on Chicago's Dan Ryan Expressway involved a tour bus and two other vehicles.
Fire Media Affairs Chief Kevin MacGregor said paramedics took 20 people to local hospitals. He said an additional 31 people on the bus refused treatment. Eight people were in good condition and 12 were in fair condition.
Northbound lanes of the expressway on the city's South Side were closed.
The crash comes less than a week a tour bus crash on a Virginia highway killed four people and sent more than 50 others to hospitals.
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