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The attacks happened near Wana, the main town in Pakistan's South Waziristan tribal area, the officials said, speaking on condition of anonymity because they were not authorized to talk to the media.
The 10 suspected militants who were killed were in the targeted compound and were believed to be allied with Maulvi Nazir, a prominent militant commander in the area, according to the officials. It wasn't immediately clear if there were casualties in the vehicle strike.
South Waziristan was the main sanctuary for the Pakistani Taliban until the army launched a large ground offensive in 2009. But militants continue to inhabit the area and often carry out attacks against Pakistani soldiers.
The U.S. does not publicly discuss drone strikes in Pakistan, but officials have said privately that they have killed several senior al-Qaida and Taliban commanders.
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