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Tony Pena (1-1) allowed two runs and three hits in one inning but earned the win.
Sergio Santos, the seventh Chicago pitcher, got four outs for his seventh save in eight chances.
"It felt a little like spring training where you all get one inning," Santos said. "You all know you'll get a chance to pitch. It made us feel like a team. You went out and did your job, now I have to do mine."
Quentin pulled a two-out solo shot into the left-field seats in the first to give the White Sox the lead.
Chicago starter Jake Peavy issued his first walk of the season in his third outing when Ian Kinsler drew a base on balls leading off the game. Kinsler advanced to second on a groundout and scored on Josh Hamilton's single.
In the third, Quentin hit a high drive into the right-field stands off Derek Holland for a 4-1 advantage, marking Quentin's 12th career multihomer game.
"That ball was hit pretty good," Guillen said. "When Carlos hits the ball, he can hit it a long way. You only see a home run like that one to the opposite field from Josh Hamilton or (Adam) Dunn or (Jim) Thome."
Young's sacrifice fly in the third pulled Texas within 4-2.
When play got back under way, both starters were done for the night.
Peavy, who allowed two runs and five hits in three innings, was replaced by Will Ohman.
Tomko came in for Holland, who gave up four runs and four hits in four innings.
NOTES: Rangers RHP Brandon Webb allowed four runs -- one earned -- and six hits during a 79-pitch outing in extended spring training in Arizona. Webb struck out five, hit two batters with pitches, and didn't issue a walk. The 2006 NL Cy Young Award winner is on the 60-day disabled list recovering from right rotator cuff surgery, with no timetable for his debut with the Rangers. ... The wind was blowing so hard in the bottom of the third that White Sox CF Alex Rios raced in to catch Nelson Cruz's flyball after Rios initially took a few steps back on the drive. ... Rangers 35-year-old RHP Yoshinori Tateyama made his major league debut, becoming the fourth Japanese native to pitch for Texas. Tateyama got two outs in the seventh, allowing one hit and one run. ... Hamilton, in his second game since missing 36 with a broken bone in his right shoulder sustained on a headfirst slide, slid headfirst into first on an infield single in the eighth. Hamilton then dove headfirst into second on a stolen base, and into third on a wild pitch before he was stranded there. "Josh is fine," said a supportive Rangers manager Ron Washington. "He's just playing baseball. It's his instincts. I don't expect him to change."
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