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Arizona rookie cornerback Patrick Peterson was asked what Manning did differently on those last two possessions.
"Honestly, he didn't do anything impressive," Peterson said. "We've just got to make plays, to be honest with you."
Going to the no-huddle got things in gear for the Giants just in time.
"They ran the ball on us, they threw the ball on us," New York coach Tom Coughlin said. "We had many occasions where we weren't able to make any first downs. For us to come back and play like we did and have an opportunity -- we still gave the ball away on the 5 -- and to overcome it, it is a real testimony for the guys to keep on playing."
Wells, who missed the previous game because of a hamstring injury, rushed for a career-best 138 yards.
The Cardinals' last gasp ended when Kevin Kolb's pass to Larry Fitzgerald from the New York 30 fell incomplete. Arizona has lost three in a row, all in the same excruciating fashion.
"I know we are learning about ourselves," Kolb said. "You get better every time you do it, but it's frustrating, especially in this case, to see them do it, then we didn't back it up. I'm sure you would get every player up here telling you, 'It's our fault, it's our fault, it's our fault.' Both sides of the ball had a chance to put the nail in the coffin and we missed out."
Fitzgerald caught eight passes for 102 yards to break the franchise records for career yards receiving and career 100-yard games. Kolb was 20 for 34 for 237 yards, with one interception and one lost fumble.
Kolb was sacked four times, twice each by Dave Tollefson and Osi Umenyiora, who played for the first time this season after coming back from arthroscopic knee surgery.
The Giants were without defensive end Justin Tuck because of neck and groin injuries that kept him out of practice most of last week.
NOTES: Arizona starting right offensive tackle Brandon Keith left the game in the second quarter with a right knee sprain. Kolb was sacked three times in the first half, twice by Dave Tollefson, and fumbled deep in New York territory. ... The Giants were making their second return to University of Phoenix Stadium since their 2008 Super Bowl triumph. They lost at Arizona 37-29 on Nov. 23, 2008. ... Fitzgerald wore pink shoes in honor of breast cancer awareness day and is a spokesman for the league-wide awareness for women to be regularly tested for the illness. His mother died of the disease.
[Associated Press;
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