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Manning had neck surgery to repair a nerve May 23, but the recovery has taken much longer than the expected 6-8 weeks that would have put him back on the field for the start of training camp. Instead, he started camp on the physically unable to perform list and wasn't activated until last Monday.
He did limited work at practice last week, which led to complaints about back pain. The team issued a statement saying that team doctors had re-evaluated Manning and instructed him to stop practicing while he undergoes more tests. No additional surgery has been scheduled.
Caldwell said the bad news only became clear Wednesday.
"We always knew it was a chance," he said. "That's what doubtful means. You always have to prepare for the worst and hope for the best."
Caldwell said he had confidence in Collins, who was lured out of retirement by the Colts as Manning's recovery dragged on.
"The guy's thrown for 40,000 yards. He can throw the ball," Caldwell said.
Collins has made 177 career starts and been to two Pro Bowls. He took the Carolina Panthers to the 1996 NFC Championship game and the New York Giants to the Super Bowl after the 2000 season. He helped Tennessee post the AFC's best record (13-3) in 2008.
Still, he has had less than two weeks to learn Indy's offense, which has traditionally called plays at the line of scrimmage. He didn't even play with Pro Bowlers Reggie Wayne or Dallas Clark in a preseason game, and the Colts will open the season with three new starters on the offensive line and a fourth, former right tackle Ryan Diem, moving inside to guard.
He also now carries the expectations of fans hoping Indy can become the first host team to play in the Super Bowl in February.
Collins says he's ready.
"I really do feel like I've come a long way in a short period of time," he said. "Now that we're into game planning, things are a little more focused and a little more centralized on what we're trying to accomplish. My comfort level is still pretty high."
[Associated Press;
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