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San Diego wasted an opportunity on its next series when it reached the Patriots 29 before Wilfork's interception. That set up a 47-yard field goal by Gostkowski on the last play of the first half, putting the Patriots on top 20-7.
After a scoreless third quarter, the Chargers made it 20-14 on a 3-yard scoring pass from Rivers to Vincent Jackson early in the fourth.
Then the Patriots tried for a first down on fourth-and-4 at the San Diego 49 because punter Zoltan Mesko had hurt his knee on a kick late in the third quarter. Brady threw an incompletion to Deion Branch, who led the Patriots with eight catches for 129 yards.
But just three plays later, New England's defense came through when Mayo forced a fumble and Ninkovich recovered at the Patriots 39. Brady needed just four plays to cover 69 yards and throw a 17-yard touchdown pass to Gronkowski. Danny Woodhead ran in for the 2-point conversion and a 28-14 lead.
The Chargers needed a comeback, but tight end Antonio Gates didn't help as he was held without a catch for the first time in 34 games.
"They would put a corner or safety on me, or two safeties," he said. "They did a lot of different things to take me out of the game."
The Chargers did score again on Rivers' 26-yard pass to Jackson with 5:40 to go. The Patriots responded with a 16-yard touchdown run by BenJarvus Green-Ellis.
But it was Brady who set that up with a 29-yard completion to Gronkowski two plays earlier. That gain put the quarterback over the 400-yard mark for the third time in his career.
"He's the best," Mayo said. "Numbers don't lie."
NOTES: Welker tied Ben Coates for the Patriots record with catches in 63 straight regular-season games. ... Former QB Drew Bledsoe and C Jon Morris were honored at halftime as new members of the Patriots Hall of Fame. ... Jackson had a career-high 10 receptions. ... Rivers went over the 20,000-yard passing mark for his career with 2,374. ... The Patriots are 15-2 in their last 17 home openers.
[Associated Press;
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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