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San Diego's Will Venable homered to straightaway center field leading off the sixth, his eighth. Jesus Guzman doubled with one out and scored on Cameron Maybin's double, which chased Coleman.
Casey Coleman (3-9) allowed two runs and five hits in 5 2-3 innings, struck out seven and walked two.
The Cubs started only three regulars. Of the other five position players who started, they had started only 93 combined games this season. There were three September callups, one August callup and Clevenger, the catcher, was making his big league debut.
"It's kid's day," Cubs manager Mike Quade laughed. "Latos is good and Bell is good and Qualls is good. That's the varsity. That's the kind of stuff you deal with up here. I wanted to see these guys against the varsity."
NOTES: Like the Padres, the Cubs have 90 losses. ... Castro singled off Latos leading off the seventh to reach base safely in a career-high 38 straight games. ... Chicago's Rafael Dolis made his big league debut when he relieved Coleman with two outs in the sixth. He got Chase Headley to ground out. ... The series continues Tuesday night with Cubs righty Matt Garza (9-10, 3.35) facing San Diego rookie righty Anthony Bass (2-0, 1.66). Garza will look to extend his winning streak to season-high four games. In his last start, he threw the eighth complete game of his career and his second this season. Bass will be making his third career start.
[Associated Press;
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