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Lewis, who had nine strikeouts in his opening day victory, struck out six with no walks against the Mariners. It was his 100th major league start in a career that began with Texas in 2002 and included two seasons in Japan before returning to the Rangers in 2010.
Alexi Ogando worked 1 1-3 innings, giving up his first run in four appearances this season when Jaso scored.
Nathan had saved his first two chances, including the Rangers' 1-0 victory Tuesday night, but lost a game Saturday night against the Chicago White Sox after giving up a leadoff homer in the ninth of a tie game.
Kevin Millwood, Seattle's oldest pitcher at 37, allowed one run with seven strikeouts and three walks over six innings in his first start of the season.
"He didn't have it early on. He was up," Wedge said. "It's a credit to him that he's able to find it. .... One of the best I've ever seen in regard to controlling damage. He did it in the first and later in the game."
Millwood was with Texas from 2006-09. The only active pitchers with more than Millwood's 2,565 1-3 career innings pitched or his 416 starts are 49-year-old Jamie Moyer and Livan Hernandez.
The back-to-back homers by Kinsler and Andrus came against right-hander Steve Delabar.
Earlier Wednesday, the Rangers announced the new deal for Kinsler, the two-time All-Star second baseman who twice in the past three seasons has had 30 homers and 30 stolen bases.
The 29-year-old Kinsler is in his seventh season, and his new deal includes a club option for 2018. He will make $7 million this season, and $13 million next year in the first year of the new contract.
Andrus, the 23-year-old shortstop in his fourth major league season, signed a three-year deal over the winter that takes him through his potential arbitration season.
NOTES: Mariners LHP Jason Vargas (1-0, 2.31 ERA) makes his third start of the season in the series finale Thursday. LHP Derek Holland pitches for the Rangers. . Rangers C Mike Napoli didn't play a night after being hit in the helmet by a pitch. Napoli said he felt fine and manager Ron Washington said the only reason he wasn't in the lineup was because it was Yorvit Torrealba's turn to catch.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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