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Vargas came back to throw a 1-2-3 seventh inning to finish a solid effort during which he allowed just four hits and a run. He struck out seven and walked three.
"I was able to locate my fastball early in the game and kind of put them on the defensive," Vargas said.
The Mariners tacked on a run in the bottom of the second when Jesus Montero walked on four pitches, pushing Brendan Ryan across the plate. But Lowe was able to get Kyle Seager to fly out to left field with the bases loaded to avoid further damage.
Cleveland shortstop Jason Donald bunted Aaron Cunningham to third after Cunningham doubled to open the third inning. Jason Kipnis' sacrifice fly to center field drove Cunningham in for Cleveland's run.
Dustin Ackley scored Ryan with a single to center to expand the Mariners' lead to 4-1. Lowe staved off a bigger inning by getting Montero to ground into a double play.
Jairo Asencio replaced Lowe and held off the Mariners in the fifth by getting Munenori Kawasaki to pop out and Ryan to ground out on a close play at first.
Seattle closer Brandon League pitched the bottom of the ninth for his fifth straight save.
NOTES: Cleveland starter Jeanmar Gomez was suspended five games Wednesday for throwing at Kansas City's Mike Moustakas last weekend. Gomez will appeal and make his normal turn in the rotation Saturday at Oakland. . Manager Manny Acta and third baseman Jack Hannahan were also fined. . Mariners third baseman Kyle Seager came into Wednesday 14 for 22 (.636) against Cleveland in his career. . Tuesday night's rally from seven down was Cleveland's largest comeback since an 11-10 win May 25, 2009 vs. Tampa Bay when the Indians entered the bottom of the fourth trailing 10-0. . Mariners catcher Adam Moore tore the medial meniscus in his right knee while playing for Triple-A Tacoma. He will have surgery Thursday. ... The plate umpire was Angel Campos
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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