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The Brewers, who have lost 12 of 16, were 2 for 22 with runners in the scoring position during the series.
Descalso, who went 3 for 4, also singled in the fifth and seventh.
Milwaukee loaded the bases in the fourth before Lohse struck out Estrada to end the threat. The Brewers put two on in the third, but Lohse got Ryan Braun to pop out.
Milwaukee third baseman Aramis Ramirez went 1 for 4 in his return to the lineup after missing the previous two games with a sore left wrist.
NOTES: The Brewers had given up six or more runs in their last five road games. ... Milwaukee pitchers have a major league-best 915 strikeouts. ... St. Louis hosts San Francisco in the first of a four-game series Monday. Jake Westbrook (10-8, 3.79 ERA) will face Matt Cain (10-4, 2.82). ... The Brewers host Cincinnati in the first of a three-game set Monday. Yovani Gallardo (9-8, 3.92) pitches against Bronson Arroyo (7-6, 3.87).
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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