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Chargers starting running back Ryan Matthews also went out in the first quarter with a shoulder injury and didn't return.
Lee, who was undrafted out of LSU, hit Vincent Brown on a 27-yard touchdown pass in the second quarter and also helped set up Curtis Brinkley's 1-yard dive that made it 21-13 with just under 2 minutes left. He finished 15 of 22.
Graham Harrell, trying to solidify his spot as the No. 2 quarterback behind Rodgers, had some bad misses early. But he hit Randall Cobb on a 23-yard pass that set up a 3-yard touchdown between the two in the closing seconds of the first half.
He was 15 of 27 for 135 yards.
Replacement officials are working games for the first time in 11 years and have 16 this weekend, including six Thursday night. There have already been some shaky moments.
The crew working the Hall of Fame game last Sunday had mixed reviews and fans in Buffalo booed replacement officials Thursday night after they muffed a touchback call in a game against Washington.
Eastin didn't seem to have any trouble in her first NFL game.
The 42-year-old from Tempe, Ariz., is a referee in the Mid-Eastern Athletic Conference, college football's second-highest level, and owns a company that trains basketball and football officials.
Wearing No. 27 on the back of her official's uniform, Eastin wasn't involved in many calls until flagging San Diego's Patrick Doyle for holding in the third quarter. She heard a few boos from the hometown crowd in the fourth period on a pass interference call on Chargers safety Corey Lynch -- she appeared to get it right -- and signaled touchdown when Green Bay's Marc Tyler scored on a 1-yard run. Green Bay failed on the 2-point conversion, keeping the Chargers up 14-13.
Eastin signaled TD again when Brinkley scored later, but had a relatively quiet night overall, which, in the world of officiating, can be a good thing.
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