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Leake was charged with three runs in six innings. He struck out five and walked two.
The right-hander cruised through five innings before Castro came through with runners on first and third. He had given up nine runs in his last two starts, a span of just 7 2-3 innings.
Rizzo got the Cubs on the board in the first with an RBI single to score David DeJesus.
Rizzo reached base four times, including a double to lead off the fourth, but the 23-year-old slugger was too aggressive on the basepaths and was thrown out at third trying to advance on Soriano's groundout.
Former first-round draft pick Brett Jackson went 0 for 3 in his home debut for Chicago.
NOTES: Cubs C Steve Clevenger was ejected in the fifth for arguing balls and strikes. ... Chicago RHP Matt Garza, out indefinitely with a stress reaction in his right elbow, said he wants to pitch again this season. "I'm hoping to (return), that's why I'm working my tail off to get back," he said. . The Reds activated C Devin Mesoraco (concussion) from the 7-day disabled list and optioned C Dioner Navarro to Triple-A Louisville. . Homer Bailey (9-7, 3.98 ERA) will pitch Friday for Cincinnati against the Cubs' Justin Germano (1-1, 3.38) in the second game of the four-game set.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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