The U.S. National Hurricane Center said the storm's center early Wednesday was about 50 miles south-southwest of New Orleans and moving slowly.
Authorities say a storm surge driven by Isaac pushed water over the top of an 18-mile stretch of levee in a thinly populated part of Plaquemines Parish.
The levee is one of many in the low-lying coastal zone. It is not part of New Orleans' defenses.
Plaquemines officials believe some people may be trapped in their homes by the flood, but they are not sure how many might still be in the area. Strong wind was hampering rescue efforts.
[Associated
Press; BY MICHAEL KUNZELMAN and STACEY PLAISANCE]
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