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Led by federal agent Jeff Novitzky, who also investigated Bonds and Clemens, U.S. authorities sought assistance overseas, requesting urine samples of U.S. Postal riders from France's anti-doping agency and also meeting with officials from Belgium, Spain and Italy.
Prosecutors also subpoenaed Armstrong supporters and ex-teammates to testify in Los Angeles. Among them were Ukrainian cyclist Yaroslav Popovych, who rode on three Armstrong teams dating back to 2005; Allen Lim, an exercise physiologist for Team Radioshack; and longtime Armstrong friend Stephanie McIlvain.
The investigation began after Novitzky was told about a cache of PEDs found by a landlord in the vacated apartment of Kyle Leogrande, a cyclist who rode for Rock Racing and had a doping ban, according to several people familiar with the case.
The case also was spurred by disgraced cyclist Floyd Landis, who claims Armstrong had a long-running doping system in place while they were teammates. Landis, who was stripped of the 2006 Tour de France title for drug use, acknowledged in 2010 he used performance-enhancing drugs after years of denying he cheated.
One of the most serious accusations came during a "60 Minutes" interview last May when former teammate Tyler Hamilton said he saw Armstrong use EPO during the 1999 Tour de France and in preparation for the 2000 and 2001 tours.
U.S. anti-doping officials said Friday they will not be dissuaded by the government's decision to close the Armstrong probe and will continue their investigation into doping in professional cycling.
As the investigation progressed, Armstrong assembled a legal team, hired a spokesman and briefly created a website to address any of the allegations reported by the media.
Frustrated by a slew of news articles about the investigation, Armstrong's attorneys filed a motion in July, asking a judge to order federal agents to testify about their contacts with reporters.
Armstrong consciously maintained a high profile throughout the investigation, raising money for his cancer charity, Livestrong, and racing in events such as off-road triathlons. He had no reason to hide, he said.
[Associated Press;
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