"The accident was messy," said government spokesman Thulani Sibuyi describing heads and limbs severed from bodies.
At least two dozen people were injured in the accident in Mpumalanga, an eastern province in South Africa, said an emergency spokesman Jeff Wicks.
A final death toll is yet to be established.
"You have scattered bodies. It is difficult to count or to come up with a conclusive number," said provincial spokesman Joseph Mabuza.
Sibuyi said that the owner of the truck is currently being questioned by the police.
Traffic accidents with high death tolls are common in South Africa, and often are blamed on negligent drivers and badly maintained roads.
In 2010, a man driving 14 children to school evaded barriers at a crossing near Cape Town and a train crashed into it, killing 10 of his young passengers. The driver was convicted of murder in the deaths of the students and attempted murder in the case of the four surviving children. He was sentenced to 20 years in prison. Transportation officials hailed the tough charges and sentence, saying that could help deter reckless driving.
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