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J.D. Martinez homered for the Astros, who have lost six straight.
The Rockies didn't need Tulowitzki in the series finale. They led 4-0 before Norris (5-2) recorded an out in the first inning.
Colorado led 5-0 after one and added four more in the second before Norris was replaced by Rhiner Cruz. Norris allowed seven hits in 1 2-3 innings and his ERA jumped from 3.34 to 4.52.
"Tough start. They've scored 15 runs in the first inning these four games," Houston manager Brad Mills said. "That'll put you behind the 8-ball pretty early. That was troublesome."
Martinez homered in the second to get Houston on the board. Juan Castro had an RBI triple, pinch-hitter Justin Maxwell doubled in a run and Jose Altuve added an RBI single in the Astros' three-run fourth.
Cuddyer had an RBI single in the fourth and Scutaro connected in the sixth, helping Guthrie (3-3) earn his first win since April 22. The right-hander, who was 0-2 with a 4.41 ERA since returning from a right shoulder strain, gave up five runs and 12 hits in seven innings.
"I gave up a lot of hits, maybe a career high, but our bats have been really hot, gave us a nice cushion and continued to tack on, which is so big," Guthrie said. "We outscored them tonight."
NOTES: The Rockies activated INF Chris Nelson (wrist) from the 15-day DL to take Tulowitzki's place on the roster. ... Houston sent pitcher J.A. Happ home early Thursday in anticipation of his start against Cincinnati on Friday. ... The Rockies will start LHP Josh Outman (0-1) in Friday's series opener against the Los Angeles Dodgers.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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