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The fourth-seeded Briton twice called for treatment on his back during the first set, and then again after losing the set. But then things started to change.
"I was a few points probably from stopping," Murray said. "I just didn't really want to stop the match. Then at the end of the second set I started standing up at the change of ends, and my back started to loosen up a little bit."
Despite being broken to open the second set, Murray started to move better. By the time he broke back for 4-4, Murray was the one getting stronger.
"I really never got the momentum back," Nieminen said.
Murray, who injured his right ankle at the French Open last year, skipped the Madrid Open with a back problem and said it was still affecting him after a three-set loss to Richard Gasquet in the third round of the Italian Open.
Isner was last on court in the main stadium, and eventually lost to Paul-Henri Mathieu of France 6-7 (2), 6-4, 6-4, 3-6, 18-16.
Two years ago, Isner beat Nicolas Mahut 70-68 in the fifth set at Wimbledon.
On Thursday, Sharapova's match had to be postponed because Isner and Mathieu played 5 hours, 41 minutes -- the second-longest by time in French Open history. The record is 6:33.
Just the last set took 2:28.
"I served well," Isner said. "Just didn't do anything else that well."
[Associated Press;
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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