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UConn, which leads the nation in scoring defense at just under 46 points a game and field goal percentage defense (30.0), was converting Kansas State's misses into easy baskets.
Hartley outscored the Wildcats in the first half. Mosqueda-Lewis, who matched the UConn record with 21 points in her NCAA debut, fell just five short of the school's two-game mark held by Maya Moore.
The Huskies led 38-10 at halftime, as the Wildcats missed 27 of their 31 shots.
It didn't get much better in the second half for Kansas State. UConn built its lead up to 46. The only question in the last few minutes was whether the Wildcats would avoid the mark for futility set by Southern.
A basket by Emma Ostermann with 2:59 left gave Kansas State 26 points, but that was the last points that the Wildcats would score.
It was the 17th time this season that the Huskies held an opponent under 40 points.
The Wildcats survived a tough test from Princeton in the opening round Saturday, beating the Tigers 67-64. Kansas State was playing the Huskies for the first time despite being in UConn's region of the NCAAs five times in the last 11 years.
Before the game, Patterson said she was impressed by UConn's defense after watching it against Prairie View in the opener. The Huskies held the Lady Panthers to just 15 points in the second half of that 83-47 victory. They continued that stellar effort against the Wildcats.
"To be honest, all year long watching them on television and film prior to this game, they've been my pick to win it all," Patterson said. "I really never pick against Connecticut. They're as versatile as you would have thought when they're shooting as well as they are on the perimeter."
With the first-round win against the Lady Panthers, UConn surpassed the 30-victory mark for the seventh straight season, matching the Division I record set by Duke from 2001-07.
"We talked about the 30 wins and how important that is to them," Auriemma said. "Going to regionals again, how rewarding it should feel for them. Those are things that sometimes people take for granted. We don't want to do that. I'm happy for this group. I'm really happy for this group."
[Associated Press;
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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