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Sale got Johnny Damon to hit a slow roller to shortstop Ramirez, who booted it for an error, loading the bases.
Kipnis grounded out to first, scoring Kotchman and Asdrubal Cabrera walked, reloading the bases. Santana then lined a ball right past Sale and into center field to tie it.
It was Sale's first outing since beating Cleveland 7-2 as a starter May 1. A reliever last year, he went 3-1 in five starts.
"I was mentally and physically ready to go, even though I hadn't been out there for a while," Sale said. "I feel bad for Johnny. We rode in together and he was pumped, saying `I'm better than that, I can beat that team.' I let him down."
Indians starter Justin Masterson made 27 pitches in the first inning, allowing five hits and falling behind 2-0.
One run scored on a groundout by Paul Konerko and A.J. Pierzynski added an RBI single.
Cleveland put a runner on third with no outs in the seventh, but Danks quickly got out of it.
Masterson struggled to throw strikes, but kept Cleveland in the game. The right-hander allowed six hits and two runs over six innings, walking five.
Pierzynski's bases-loaded RBI groundout made it 3-0 in the seventh off reliever Dan Wheeler.
NOTES: Ramirez went 0 for 5 and is in a 3 for 24 slump. ... Cleveland LHP Nick Hagadone struck out the side in the ninth, one day after earning his first career save. ... When Hagadone and Tony Sipp saved both ends of a doubleheader Monday, it was the first time since the save became an official statistic in 1969 that two different Cleveland lefties did it in a twinbill. ... In the first game, LHP Jose Quintana worked 5 2-3 scoreless innings, the longest scoreless stretch by a White Sox pitcher in his major-league debut since Jack McDowell's seven scoreless in 1987.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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