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Headley hit a tying homer leading off the fourth, then tied it again with a two-run drive in the fifth.
It was Headley's second multihomer game of the year. He has seven home runs this season after hitting just four in 113 games in 2011.
"When it's hot and you come here and the wind's blowing, you're going to be rewarded for good swings," Headley said. "When the conditions are like that, you know you have to put up a good amount of runs to be able to win the game."
Carlos Quentin hit an RBI double in his Padres' debut to give San Diego a 1-0 lead and snap their streak of 26 scoreless innings.
Quentin was activated from the 15-day disabled list prior to the game. He had arthroscopic surgery on his right knee in March after being acquired from the Chicago White Sox on Dec. 31.
DeJesus got the Cubs going in the first with a leadoff triple and scoring on Castro's single. Castro stole second and later scored on Bryan LaHair's groundout.
Cubs starter Travis Wood lasted just five innings. He was tagged for a season-high six runs on seven hits, including four home runs.
San Diego starter Jeff Suppan yielded six runs over five innings.
NOTES: Cabrera's solo shot in the fourth was his first homer since July 11, 2010. ... The Padres optioned OF Blake Tekotte to Triple-A Tucson to make room on the roster for Quentin. ... San Diego OF Cameron Maybin (sprained right wrist) missed his second straight game after leaving in the sixth inning Saturday. He remains day-to-day. ... Padres RHP Huston Street (right shoulder strain) felt "really good" after throwing off a mound Sunday, Black said. He is scheduled to throw another bullpen on Wednesday. ... The Cubs activated RHP Carlos Marmol from the 15-day DL and optioned RHP Rafael Dolis to Triple-A Iowa. ... Jeff Samardzija (4-3, 3.00 ERA) will pitch for the Cubs on Tuesday against San Diego's Eric Stults (1-0, 1.96).
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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