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Pierzynski followed with a grounder up the middle off reliever Joe Smith that went off diving second baseman Jason Kipnis' glove and into center field as Konerko scored. Viciedo's single then scored Rios to give the White Sox a 4-0 lead and chance to breathe a little easier.
Santiago was never threatened by the Indians, who managed just three baserunners off the left-hander. Cleveland did not get a runner to second base off Santiago, who won for the first time in five starts.
Dunn added an RBI single in the ninth to make it 6-0.
The White Sox didn't seem to be feeling any pressure before the game. Players sat in front of their lockers, tapping away at the screens of their iPads or watching TV as if it was June 1 and not Oct. 1 with their season hanging by a thread.
Chicago's players, who had spent 117 total days in first place, seemed resigned to their fate.
"If it does become official, it's a huge disappointment," said starter Jake Peavy, who is scheduled to start Tuesday's game. "We feel like we let one slip away. It's extremely frustrating the way things have played out."
It was a monumental collapse for the White Sox, who led the division by three games on Sept. 17. Since then, they're 4-10 and now have to hope the Royals can somehow sweep three straight from the Tigers.
As for the Indians, they dropped to 2-2 under interim manager Sandy Alomar Jr., who hopes to become Cleveland's permanent manager.
"It'd be great. It'd be awesome," Alomar said before the game. "I played here many years. I'm very proud of this organization. They have treated me great. They brought me back. If it's the time, it's their choice. If it's the time, it's time. if not, there will be some other time."
Alomar took over last week when the Indians fired Manny Acta with six games left. Alomar, who served Acta's bench coach this season, will likely interview with the Indians by the end of the week. He and former Boston Red Sox manager Terry Francona are the only candidates confirmed so far by the club, which has tentatively set up a meeting with Francona on Friday.
NOTES: Pierzynski has 77 RBIs, matching a career-high. ... With his performance, Santiago helped Chicago's set a club record for strikeouts in a season. The White Sox have fanned 1,225 batters, five more than in 2011. ... Dunn has 220 strikeouts, three away from the major league record set by Mark Reynolds with Arizona in 2009. ... Santiago's 10 strikeouts were the most by a Chicago rookie since Jason Bere, who struck out 12 Angels on Sept. 20, 19093.
[Associated
Press;
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