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Santiago got help from reliever Nate Jones and Donnie Veal as they stranded Darin Mastroianni at third in the sixth inning.
Youkilis doubled with one out in the seventh off Minnesota reliever Kyle Waldrop. Then with two outs Youkilis scored on Paul Konerko's single to extend the lead to 3-1. Youkilis earlier snapped out of an 0-for-19 skid and was 2 for 3 on the night.
Joe Mauer doubled in the eighth off reliever Matt Thornton and scored on Justin Morneau's single to get Minnesota back within one run.
Beckham gave the White Sox an insurance run with his third RBI of the game in the eighth. Alexei Ramirez hit a two-out single then stole second and scored on Beckham's single.
NOTES: The White Sox held a pregame tribute for former reliever and assistant coach Kevin Hickey, who died on May 14. The White Sox dedicated the batting cage in his name. ... Twins are expected to call up INF Eduardo Escobar from Triple-A Rochester on Tuesday. Escobar was acquired from the White Sox in the Francisco Liriano deal. Minnesota also plans to call up reliever Luis Perdomo from Rochester on Tuesday. ... Josh Willingham was back in the lineup as the designated hitter after missing a game with a sore hamstring. He was 0 for 4.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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