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The Pirates had a chance to tie it with a Starling Marte leadoff triple in the seventh, but Marte was caught in a rundown on a fake to third, throw to first by Cubs reliever Jaye Chapman after Neil Walker and McCutchen failed to get the run in.
"Actually that's a forced balk, break late try to get the run to second and try to steal a run at home is what it was," Pirates manager Clint Hurdle explained. "I do believe if Starling could've shown a little more patience that play would have worked for us, but in the heat of the moment he left a little bit early."
Jeff Beliveau (1-0) allowed Alvarez's second home run, but recorded the final two outs of the sixth to earn his first career win.
Barajas homered on an 0-2 pitch with a man on and the pitcher on deck in the second inning to reach double-digits for the year.
McCutchen had an RBI single in the second and reached base four times. He has reached safely in nine of his last 11 plate appearances this series.
Pirates starter Jeff Locke was backed by a consistent flow of Pittsburgh offense, but couldn't get through the fifth inning to earn his first big league victory.
The 24-year-old Locke was staked to a 6-1 lead until things fell apart in a four-run fifth.
Mather's one-out solo homer started a string of four straight hits for the Cubs, which included Rizzo's two-run shot.
Cubs starter Chris Volstad had trouble finding the strike zone, and was hit hard when he did. The big righty gave up six runs on 10 hits through 4 2-3 innings. He walked four and struck out three.
Volstad had won three of his last four starts after enduring a brutal 24-start winless skid that spanned 13 months.
Alfonso Soriano drove in his 100th run of the season with a first-inning single to bring home Rizzo. It's Soriano's third career 100-RBI season, and first since 2005 when he had a career-high 104 with Texas.
NOTES: Pirates manager Clint Hurdle removed RHP James McDonald from the starting rotation due to a poor second half. RHP Kyle McPherson will take McDonald's turn in the rotation Wednesday against Milwaukee. McDonald is 3-5 with a 7.08 ERA since the All-Star break. ... Chicago sends LHP Travis Wood (6-11, 4.23 ERA) to the mound in the series finale Monday against Pittsburgh's RHP Kevin Correia (10-9, 4.29).
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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