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The Orioles jumped on starter Hector Noesi (2-12) from the first batter and didn't let up until they chased him after just 1 1-3 innings.
McLouth opened the game with a home run into the right-field seats on an 0-2 pitch. Reynolds and Manny Machado each had an RBI single later in the first.
J.J. Hardy and Reynolds each had a run-scoring double in a four-run second, and Jones added an RBI single. Another run scored on an error for a 7-0 lead.
"It's everyone picking the next guy up," Reynolds said. "We need guys to get hot right now to stay in this race. The Yankees aren't going anywhere. Oakland is a good team. Tampa Bay is right there. The Angels are a really good team. We have to take care of our own by winning games. Whether it's Wieters or Jonesy or someone else, everyone has to step up."
Noesi gave up eight hits and six earned runs in his 54-pitch outing. He walked two and struck out one.
"Hector has to be better than that," Wedge said. "It just wasn't a good day at all for him."
Wieters hit a two-run homer to center in the fourth on the first pitch from Oliver Perez. It was his 22nd, tying his career high.
Endy Chavez finished the Orioles' scoring with an RBI single in the sixth.
"That's impressive, our production around," McLouth said. "Definitely not counting on one or two guys alone is pretty important."
NOTES: The Orioles have won six of seven meetings with the Mariners this season. ... Showalter said he's "pleasantly surprised" that OF Nick Markakis does not need more surgery on his injured right thumb. Markakis was hurt Sept. 8 and was given a six-week timetable for a return. It's unlikely he'll be available unless the club advances well into the playoffs. ... Orioles RHP Jason Hammel, who came out of his start last Tuesday with a knee issue, is progressing slowly, according to Showalter. It's uncertain when he will start again. ... Baltimore RHP Miguel Gonzalez likely will start Friday in Boston. ... Wedge started his regulars. "We are going to put out our best lineup," he said. He added that his players are doing more than just showing up. "No one is looking at the finish line right now," he said. "I don't sense that at all. They're all focused on today."
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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