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Chicago starter Chris Rusin (1-3) allowed six runs on seven hits in 3 2-3 innings.
McBride hit a three-run homer off Rafael Dolis in the fifth to make it 9-5.
Sappelt led off the game with his first major league home run. The Cubs scored two more runs in the first on shortstop Rutledge's throwing error and Wellington Castillo's double.
Rosario's 27th homer of the year leading off the second made it 3-1. Castro hit a solo shot to center in the fourth to give the Cubs a 4-1 lead.
Colorado cut the lead to 4-3 in their half of the fourth on Tyler Colvin's two-run triple to right.
NOTES: Sappelt's home was his first in 153 major league at-bats. ... An MRI on Rockies OF Carlos Gonzalez's left hamstring was negative. Gonzalez didn't start for the eighth straight game while he nurses the tight ligament. ... Colorado OF Dexter Fowler (left wrist tendinitis) was out of the lineup for the third straight game.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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