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Kluber (2-4) gave up four hits in seven innings, retiring nine of his last 10 batters. Vinnie Pestano and Perez completed the six-hitter, with Perez gaining his 37th save in 41 chances.
"He grew a little as a pitcher today," Indians manager Manny Acta said of Kluber. "That was a well-pitched ballgame, a crucial situation for (the White Sox)."
Russ Canzler had three hits and homered for the second straight game, putting Cleveland ahead in the second inning.
Canzler doubled between a pair of walks as the Indians loaded the bases with one out in the fourth, and Thomas Neal barely beat out a potential double-play grounder as Carlos Santana scored.
Upset by first base umpire Jerry Layne's call, Pierzynski jumped up and down at home plate.
Ezequiel Carrera and Shin-Soo Choo followed with consecutive RBI singles that chased Liriano.
NOTES: Pierzynski has a career-best 27 homers. Only Carlton Fisk has more homers in a season by a White Sox catcher, with 37 in 1985. ... Chicago has hit back-to-back homers 10 times this year. ... The teams are a combined 2 for 8 in steal attempts this series. ... White Sox manager Robin Ventura shuffled his rotation, giving starter Jake Peavy an extra day of rest. Peavy will pitch the series opener against the Rays on Thursday, and lefty Hector Santiago (3-1, 3.45 ERA) was plugged in for the series finale against Cleveland on Wednesday. The Indians start RHP Justin Masterson (11-15, 4.97). ... Ventura said LHP Chris Sale was going to get an extra day of rest prior to the game, but the team announced after the game that he would pitch Saturday on regular rest. ... Cleveland RHP Roberto Hernandez (sprained right ankle) will throw three innings in a simulated game Wednesday. Acta said Hernandez will possibly throw one more simulated game after that and be done for the season.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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